Publications
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(Jul 2019) Comparison of Biomarker Modalities for Predicting Response to PD-1/PD-L1 Checkpoint Blockade
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(Mar 2019) Multiplexed Immunohistochemistry for Molecular and Immune Profiling in Lung Cancer—Just About Ready for Prime-Time?
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(Sep 2019) Phenotypic Plasticity of Fibroblasts during Mammary Carcinoma Development
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(Feb 2019) A Human iPSC-derived 3D platform using primary brain cancer cells to study drug development and personalized medicine
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(May 2016) Multispectral Imaging of T and B Cells in Murine Spleen and Tumor
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(Sep 2015) Nivolumab and Urelumab Enhance Antitumor Activity of Human T Lymphocytes Engrafted in Rag2-/-IL2Rγnull Immunodeficient Mice
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(Aug 2015) Noncatalytic PTEN missense mutation predisposes to organ-selective cancer development in vivo
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(Feb 2017) Distinct patterns of infiltrating CD8+ T cells in HPV+ and CD68 macrophages in HPV- oropharyngeal squamous cell carcinomas are associated with better clinical outcome but PD-L1 expression is not prognostic
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(2011) Reversal of glial and neurovascular markers of unhealthy brain aging by exercise in middle-aged female mice
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(2012) Spectral imaging in preclinical research and clinical pathology
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(2015) Multispectral Imaging of Pancreatic Mixed Acinar-neuroendocrine-ductal Carcinoma with Triple-immunoenzyme Staining
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(Apr 2014) The pathology of severe dengue in multiple organs of human fatal cases: histopathology, ultrastructure and virus replication
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(Apr 2016) OX40, PD-1 and CTLA-4 are selectively expressed on tumor-infiltrating T cells in head and neck cancer
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(Apr 2017) Spatial computation of intratumoral T cells correlates with survival of patients with pancreatic cancer
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(Apr 2018) Multispectral imaging for quantitative and compartment-specific immune infiltrates reveals distinct immune profiles that classify lung cancer patients
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(Apr 2018) An automated staining protocol for seven-colour immunofluorescence of human tissue sections for diagnostic and prognostic use.
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(Apr 2018) Quantitative Analysis of Immune Infiltrates in Primary Melanoma
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(Aug 2010) Quantitative, architectural analysis of immune cell subsets in tumor-draining lymph nodes from breast cancer patients and healthy lymph nodes
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(Aug 2015) PD-1 and CD103 Are Widely Coexpressed on Prognostically Favorable Intraepithelial CD8 T Cells in Human Ovarian Cancer
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(Aug 2015) Quantum dot-based multispectral fluorescent imaging to quantitatively study co-expressions of Ki67 and HER2 in breast cancer
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(Aug 2015) Reducing GBA2 Activity Ameliorates Neuropathology in Niemann-Pick Type C Mice
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(Aug 2018) Single-cell profiling of breast cancer T cells reveals a tissue-resident memory subset associated with improved prognosis
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(Dec 2015) Cabozantinib Inhibits Abiraterone's Upregulation of IGFIR Phosphorylation and Enhances Its Anti-Prostate Cancer Activity
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(Dec 2016) A Comparative Performance Analysis of MSI and RGB imaging on HER2 Status Evaluation for Prediction of Breast Cancer Prognosis
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(Feb 2014) Correlation of Nrf2, NQO1, MRP1, cmyc and p53 in colorectal cancer and their relationships to clinicopathologic features and survival
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(Feb 2015) Angels and demons: Th17 cells represent a beneficial response, while neutrophil IL-17 is associated with poor prognosis in squamous cervical cancer
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(Feb 2016) The tumor microenvironment and immunoscore are critical determinants of dissemination to distant metastasis
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(Feb 2017) Infiltration of CD8 T Cells and Expression of PD-1 and PD-L1 in Synovial Sarcoma
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(Feb 2017) Interaction between tumour-infiltrating B cells and T cells controls the progression of hepatocellular carcinoma
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(Feb 2018) Increased immune infiltration and chemokine receptor expression in head and neck epithelial tumors after neoadjuvant immunotherapy with the IRX-2 regimen
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(Feb 2018) Multispectral imaging reveals hyper active TGF-β signaling in colorectal cancer
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(Jan 2013) A colorful future of quantitative pathology: validation of Vectra technology using chromogenic multiplexed immunohistochemistry and prostate tissue microarrays
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(Jan 2014) Multispectral imaging: a review of its technical aspects and applications in anatomic pathology
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(Jan 2017) Differential Expression and Significance of PD-L1, IDO-1, and B7-H4 in Human Lung Cancer
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(Jan 2020) B cells and tertiary lymphoid structures promote immunotherapy response
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(Jan 2020) B cells are associated with survival and immunotherapy response in sarcoma
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(Jan 2020) Tertiary lymphoid structures improve immunotherapy and survival in melanoma
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(Jul 2010) Enhancing the delivery of anti-retroviral drug "Saquinavir" across the blood brain barrier using nanoparticles
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(Jul 2014) Pioglitazone treatment reduces adipose tissue inflammation through reduction of mast cell and macrophage number and by improving vascularity
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(Jul 2015) Prognostic significance of full-length estrogen receptor beta expression in stage I-III triple negative breast cancer
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(Jul 2016) Quantitative assessment of the spatial heterogeneity of tumor-infiltrating lymphocytes in breast cancer
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(Jul 2017) Multiparametric immune profiling in HPV- oral squamous cell cancer
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(July 2014) Automated quantitative multiplex immunofluorescence in situ imaging identifies phospho-S6 and phospho-PRAS40 as predictive protein biomarkers for prostate cancer lethality
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(Jun 2013) Sex steroid receptor expression and localization in benign prostatic hyperplasia varies with tissue compartment
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(Jun 2016) T-cell Landscape in a Primary Melanoma Predicts the Survival of Patients with Metastatic Disease after Their Treatment with Dendritic Cell Vaccines
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(Jun 2017) Combined immune checkpoint blockade as a therapeutic strategy for BRCA1-mutated breast cancer
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(Mar 2011) Loss of neuronal integrity during progressive HIV-1 infection of humanized mice
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(Mar 2011) Smooth muscle homeostasis in human atherosclerotic plaques through interleukin 15 signalling
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(Mar 2013) Differences in expression patterns of cathepsin C/dipeptidyl peptidase I in normal, pathological and aged mouse central nervous system
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(Mar 2015) Vimentin regulates activation of the NLRP3 inflammasome
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(Mar 2017) VISTA is an inhibitory immune checkpoint that is increased after ipilimumab therapy in patients with prostate cancer
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(Mar 2018) Germinal Centers Determine the Prognostic Relevance of Tertiary Lymphoid Structures and Are Impaired by Corticosteroids in Lung Squamous Cell Carcinoma
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(Mar 2018) An RNA-Based Digital Circulating Tumor Cell Signature Is Predictive of Drug Response and Early Dissemination in Prostate Cancer
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(Mar 2018) Spatial interaction of tumor cells and regulatory T cells correlates with survival in non-small cell lung cancer
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(May 2011) Optimal tumor sampling for immunostaining of biomarkers in breast carcinoma
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(May 2014) Analysis and validation of tissue biomarkers for renal cell carcinoma using automated high-throughput evaluation of protein expression
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(May 2014) Pancreatic ductal adenocarcinoma contains an effector and regulatory immune cell infiltrate that is altered by multimodal neoadjuvant treatment
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(May 2015) Ipilimumab-dependent cell-mediated cytotoxicity of regulatory T cells ex vivo by nonclassical monocytes in melanoma patients
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(May 2016) Targeting MET and AXL overcomes resistance to sunitinib therapy in renal cell carcinoma
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(May 2017) Liver Metastasis and Treatment Outcome with Anti-PD-1 Monoclonal Antibody in Patients with Melanoma and NSCLC
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(May 2017) IL-10 improves cardiac remodeling after myocardial infarction by stimulating M2 macrophage polarization and fibroblast activation
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(May 2018) Gut microbiome-mediated bile acid metabolism regulates liver cancer via NKT cells
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(Nov 2014) Multiplexed immunohistochemistry, imaging, and quantitation: a review, with an assessment of Tyramide signal amplification, multispectral imaging and multiplex analysis
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(Nov 2015) SIGIRR/TIR8, an important regulator of TLR4 and IL-1R-mediated NF-κB activation, predicts biochemical recurrence after prostatectomy in low-grade prostate carcinomas
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(Nov 2017) Eight-Color Multiplex Immunohistochemistry for Simultaneous Detection of Multiple Immune Checkpoint Molecules within the Tumor Microenvironment
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(Nov 2017) Topological analysis reveals a PD-L1-associated microenvironmental niche for Reed-Sternberg cells in Hodgkin lymphoma
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(Oct 2014) CXCL17 expression predicts poor prognosis and correlates with adverse immune infiltration in hepatocellular carcinoma
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(Oct 2015) Automated prognostic pattern detection shows favourable diffuse pattern of FOXP3(+) Tregs in follicular lymphoma
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(Oct 2015) Multispectral Imaging Approach to the Diagnosis of a CD20+ Cutaneous T-cell Lymphoproliferative Disorder: A Case Report
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(Oct 2015) Multispectral imaging of formalin-fixed tissue predicts ability to generate tumor-infiltrating lymphocytes from melanoma
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(Sep 2015) Epithelial-to-mesenchymal transition induces cell cycle arrest and parenchymal damage in renal fibrosis
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(Sep 2015) Stromal infiltration of CD8 T cells is associated with improved clinical outcome in HPV-positive oropharyngeal squamous carcinoma
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(Sep 2016) Mutations Associated with Acquired Resistance to PD-1 Blockade in Melanoma
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(Sep 2017) Monolithic Chip for Highthroughput Blood Cell Depletion to Sort Rare Circulating Tumor Cells