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(Jul 2019) Comparison of Biomarker Modalities for Predicting Response to PD-1/PD-L1 Checkpoint Blockade
(Mar 2019) Multiplexed Immunohistochemistry for Molecular and Immune Profiling in Lung Cancer—Just About Ready for Prime-Time?
(Sep 2019) Phenotypic Plasticity of Fibroblasts during Mammary Carcinoma Development
(Feb 2019) A Human iPSC-derived 3D platform using primary brain cancer cells to study drug development and personalized medicine
(Apr 2019) IL-38 Ameliorates Skin Inflammation and Limits IL-17 Production from γδ T Cells
(Apr 2019) Multi-institutional TSA-amplified Multiplexed Immunofluorescence
(May 2016) Multispectral Imaging of T and B Cells in Murine Spleen and Tumor
(Sep 2015) Nivolumab and Urelumab Enhance Antitumor Activity of Human T Lymphocytes Engrafted in Rag2-/-IL2Rγnull Immunodeficient Mice
(Aug 2015) Noncatalytic PTEN missense mutation predisposes to organ-selective cancer development in vivo
(Feb 2017) Distinct patterns of infiltrating CD8+ T cells in HPV+ and CD68 macrophages in HPV- oropharyngeal squamous cell carcinomas are associated with better clinical outcome but PD-L1 expression is not prognostic
(2011) Reversal of glial and neurovascular markers of unhealthy brain aging by exercise in middle-aged female mice
(2012) Spectral imaging in preclinical research and clinical pathology
(2015) Multispectral Imaging of Pancreatic Mixed Acinar-neuroendocrine-ductal Carcinoma with Triple-immunoenzyme Staining
(Apr 2014) The pathology of severe dengue in multiple organs of human fatal cases: histopathology, ultrastructure and virus replication
(Apr 2016) OX40, PD-1 and CTLA-4 are selectively expressed on tumor-infiltrating T cells in head and neck cancer
(Apr 2017) Spatial computation of intratumoral T cells correlates with survival of patients with pancreatic cancer
(Apr 2018) Multispectral imaging for quantitative and compartment-specific immune infiltrates reveals distinct immune profiles that classify lung cancer patients
(Apr 2018) An automated staining protocol for seven-colour immunofluorescence of human tissue sections for diagnostic and prognostic use.
(Apr 2018) Quantitative Analysis of Immune Infiltrates in Primary Melanoma
(Apr 2019) Quantifying tumor heterogeneity and mapping complex immune cell interactions with high-throughput, 7-color multispectral slide scans
(Aug 2010) Quantitative, architectural analysis of immune cell subsets in tumor-draining lymph nodes from breast cancer patients and healthy lymph nodes
(Aug 2015) PD-1 and CD103 Are Widely Coexpressed on Prognostically Favorable Intraepithelial CD8 T Cells in Human Ovarian Cancer
(Aug 2015) Quantum dot-based multispectral fluorescent imaging to quantitatively study co-expressions of Ki67 and HER2 in breast cancer
(Aug 2015) Reducing GBA2 Activity Ameliorates Neuropathology in Niemann-Pick Type C Mice
(Aug 2018) Deep Profiling of Mouse Splenic Architecture with CODEX Multiplexed Imaging
(Aug 2018) Single-cell profiling of breast cancer T cells reveals a tissue-resident memory subset associated with improved prognosis
(Dec 2015) Cabozantinib Inhibits Abiraterone's Upregulation of IGFIR Phosphorylation and Enhances Its Anti-Prostate Cancer Activity
(Dec 2016) A Comparative Performance Analysis of MSI and RGB imaging on HER2 Status Evaluation for Prediction of Breast Cancer Prognosis
(Feb 2014) Correlation of Nrf2, NQO1, MRP1, cmyc and p53 in colorectal cancer and their relationships to clinicopathologic features and survival
(Feb 2015) Angels and demons: Th17 cells represent a beneficial response, while neutrophil IL-17 is associated with poor prognosis in squamous cervical cancer
(Feb 2016) The tumor microenvironment and immunoscore are critical determinants of dissemination to distant metastasis
(Feb 2017) Infiltration of CD8 T Cells and Expression of PD-1 and PD-L1 in Synovial Sarcoma
(Feb 2017) Interaction between tumour-infiltrating B cells and T cells controls the progression of hepatocellular carcinoma
(Feb 2018) Increased immune infiltration and chemokine receptor expression in head and neck epithelial tumors after neoadjuvant immunotherapy with the IRX-2 regimen
(Feb 2018) Multispectral imaging reveals hyper active TGF-β signaling in colorectal cancer
(Jan 2013) A colorful future of quantitative pathology: validation of Vectra technology using chromogenic multiplexed immunohistochemistry and prostate tissue microarrays
(Jan 2014) Multispectral imaging: a review of its technical aspects and applications in anatomic pathology
(Jan 2017) Differential Expression and Significance of PD-L1, IDO-1, and B7-H4 in Human Lung Cancer
(Jan 2019) Primary Antibodies and Opal Pairings for Multiplex IHC
(Jan 2020) B cells and tertiary lymphoid structures promote immunotherapy response
(Jan 2020) B cells are associated with survival and immunotherapy response in sarcoma
(Jan 2020) Tertiary lymphoid structures improve immunotherapy and survival in melanoma
(Jul 2010) Enhancing the delivery of anti-retroviral drug "Saquinavir" across the blood brain barrier using nanoparticles
(Jul 2014) Pioglitazone treatment reduces adipose tissue inflammation through reduction of mast cell and macrophage number and by improving vascularity
(Jul 2015) Prognostic significance of full-length estrogen receptor beta expression in stage I-III triple negative breast cancer
(Jul 2016) Quantitative assessment of the spatial heterogeneity of tumor-infiltrating lymphocytes in breast cancer
(Jul 2017) Multiparametric immune profiling in HPV- oral squamous cell cancer
(July 2014) Automated quantitative multiplex immunofluorescence in situ imaging identifies phospho-S6 and phospho-PRAS40 as predictive protein biomarkers for prostate cancer lethality
(Jun 2013) Sex steroid receptor expression and localization in benign prostatic hyperplasia varies with tissue compartment
(Jun 2016) T-cell Landscape in a Primary Melanoma Predicts the Survival of Patients with Metastatic Disease after Their Treatment with Dendritic Cell Vaccines
(Jun 2017) Combined immune checkpoint blockade as a therapeutic strategy for BRCA1-mutated breast cancer
(Mar 2011) Loss of neuronal integrity during progressive HIV-1 infection of humanized mice
(Mar 2011) Smooth muscle homeostasis in human atherosclerotic plaques through interleukin 15 signalling
(Mar 2013) Differences in expression patterns of cathepsin C/dipeptidyl peptidase I in normal, pathological and aged mouse central nervous system
(Mar 2015) Vimentin regulates activation of the NLRP3 inflammasome
(Mar 2017) VISTA is an inhibitory immune checkpoint that is increased after ipilimumab therapy in patients with prostate cancer
(Mar 2018) Germinal Centers Determine the Prognostic Relevance of Tertiary Lymphoid Structures and Are Impaired by Corticosteroids in Lung Squamous Cell Carcinoma
(Mar 2018) An RNA-Based Digital Circulating Tumor Cell Signature Is Predictive of Drug Response and Early Dissemination in Prostate Cancer
(Mar 2018) Spatial interaction of tumor cells and regulatory T cells correlates with survival in non-small cell lung cancer
(May 2011) Optimal tumor sampling for immunostaining of biomarkers in breast carcinoma
(May 2014) Analysis and validation of tissue biomarkers for renal cell carcinoma using automated high-throughput evaluation of protein expression
(May 2014) Pancreatic ductal adenocarcinoma contains an effector and regulatory immune cell infiltrate that is altered by multimodal neoadjuvant treatment
(May 2015) Ipilimumab-dependent cell-mediated cytotoxicity of regulatory T cells ex vivo by nonclassical monocytes in melanoma patients
(May 2016) Targeting MET and AXL overcomes resistance to sunitinib therapy in renal cell carcinoma
(May 2017) Liver Metastasis and Treatment Outcome with Anti-PD-1 Monoclonal Antibody in Patients with Melanoma and NSCLC
(May 2017) IL-10 improves cardiac remodeling after myocardial infarction by stimulating M2 macrophage polarization and fibroblast activation
(May 2018) Gut microbiome-mediated bile acid metabolism regulates liver cancer via NKT cells
(Nov 2014) Multiplexed immunohistochemistry, imaging, and quantitation: a review, with an assessment of Tyramide signal amplification, multispectral imaging and multiplex analysis
(Nov 2015) SIGIRR/TIR8, an important regulator of TLR4 and IL-1R-mediated NF-κB activation, predicts biochemical recurrence after prostatectomy in low-grade prostate carcinomas
(Nov 2017) Eight-Color Multiplex Immunohistochemistry for Simultaneous Detection of Multiple Immune Checkpoint Molecules within the Tumor Microenvironment
(Nov 2017) Topological analysis reveals a PD-L1-associated microenvironmental niche for Reed-Sternberg cells in Hodgkin lymphoma
(Oct 2014) CXCL17 expression predicts poor prognosis and correlates with adverse immune infiltration in hepatocellular carcinoma
(Oct 2015) Automated prognostic pattern detection shows favourable diffuse pattern of FOXP3(+) Tregs in follicular lymphoma
(Oct 2015) Multispectral Imaging Approach to the Diagnosis of a CD20+ Cutaneous T-cell Lymphoproliferative Disorder: A Case Report
(Oct 2015) Multispectral imaging of formalin-fixed tissue predicts ability to generate tumor-infiltrating lymphocytes from melanoma
(Oct 2018) CODEX®: a novel platform for spatially-resolved deep biomarker profiling of single cells in tissue samples
(Oct 2018) Multiparametric Proteomic Profiling Via Imaging Dozens of Biomarkers Simultaneously
(Oct 2018) Overcoming Limitations of Conventional Fluorescence Slide Scanning with Multispectral Approaches
(Oct 2018) Phenoptics 2.0 Advances Multiplex Fluorescence Immunohistochemistry: 9-color Imaging; Whole Slide Multispectral
(Oct 2018) Phenoptics 2.0 Workflows and Applications for Whole Slide Multispectral Imaging
(Oct 2018) Spatially-resolved deep biomarker profiling of single cells in FFPE tissue samples through CODEX®
(Sep 2015) Epithelial-to-mesenchymal transition induces cell cycle arrest and parenchymal damage in renal fibrosis
(Sep 2015) Stromal infiltration of CD8 T cells is associated with improved clinical outcome in HPV-positive oropharyngeal squamous carcinoma
(Sep 2016) Mutations Associated with Acquired Resistance to PD-1 Blockade in Melanoma
(Sep 2017) Monolithic Chip for Highthroughput Blood Cell Depletion to Sort Rare Circulating Tumor Cells
Garbage in, garbage out: A critical evaluation of strategies used for validation of immunohistochemical biomarkers
Guide to Explore! Proxima
Guided Tour of a 7 Color MOTIF™ Digital Slide (video)
IHC Guidebook: Sixth Edition from Dako
inForm® Rules-Based PD-1/PD-L1 Panel Lung Cancer Phenotyping Algorithm
inForm® Rules-Based PD-1/PD-L1 Panel Melanoma Phenotyping Algorithm
Next Generation Cancer Treatment: Patient Stratification with Immuno-Oncology (video)
Opal Bench Tips (video)
Proxima User Documentation
Value of Autofluorescence Isolation Using MOTiF™ Whole Slide Multispectral Technology (video)
Vectra Polaris: Under the Hood (video)
Whole Slide Multiplex Tissue Analysis with Vectra Polaris (video)